Advances in molecular neuroimaging

Featuring
Victor L Villemagne,
Neil Vasdev, Agnetta Nordberg and Marta Marquié.

Molecular biomarkers of neurodegeneration

Featuring
Henrik Zetterberg,
Michelle M Mielke, Charlotte Teunissen and Agustín Ruiz.

Blood circulating factors contributing to dementia pathophysiology

Featuring
Tony Wyss-Coray, Berislav Zlokovic, Chris R Butler and Mercè Boada.

What is Global Research Summit?

Global Research Summit, organized by Ace Alzheimer Center with the collaboration of Grifols, arises in a context of pandemic with the aim of continuing to promote knowledge forums among the scientific community dedicated to research on dementias and Alzheimer's disease. Through different online seminars, experts from all over the world will discuss current issues and novelties in the field of dementia research.

Ace Alzheimer Center is an international reference entity in research, especially in clinical, neuropsychological, social and basic research. In addition to over 15 active research projects, Ace Alzheimer Center currently participates in 17 clinical trials targeting all phases of Alzheimer's disease.

2021 SPEAKERS

Dr. Victor L Villemagne

Visiting Professor of Psychiatry at University of Pittsburgh

Dr. Neil Vasdev

Director of the Brain Health Imaging Centre at CAMH

Dr. Agneta Nordberg

Professor at Karolinska Institutet

Dr. Marta Marquié

Deputy Director of the Clinical Research Program at Ace Alzheimer Center Barcelona

Dr. Henrik Zetterberg

Professor and Chief Physician at Institute of Neuroscience and Physiology (University of Gothenburg)

Dr. Michelle M. Mielke

Professor of Epidemiology and Neurology at Mayo Clinic

Dr. Charlotte Teunissen

Professor in Neurochemistry at VUmc

Dr. Agustín Ruiz

Chief Scientific Officer at Ace Alzheimer Center Barcelona

Mercè Boada

Co-founder and Chief Medical Officer at Ace Alzheimer Center Barcelona

Tony Wyss-Coray

Professor of Neurology and Neurological Sciences at Stanford University

Berislav Zlokovic

Director of the Zilkha Neurogenetic Institute and Professor and Chair of the Department of Physiology & Neuroscience at the Keck School of Medicine of USC

Chris R Butler

Clinical Senior Lecturer and Honorary Consultant Neurologist in the Department of Brain Sciences at Imperial College London

Program

Advances in Molecular Neuroimaging

4:30 p.m
Marta Marquié

Welcome

Marta Marquié, neurologist at Ace Alzheimer Center, will welcome attendees and speakers to the Global Research Summit 2021.
4:40 p.m
Victor L Villemagne

Emerging PET: Astroglial neuroimaging markers

Victor L Villemagne has a vast career that places him as a world leader in neuroimaging. Among his findings, stands out the fact that the process of accumulation of beta-amyloid protein in the brain - which is known to be relevant for Alzheimer's disease - can be detected through PET images between 15 and 20 years before the onset of dementia, a statement that has had a great impact on diagnosis.
5:05 p.m
Neil Vasdev

Emerging PET Radiotracers and Targets for Imaging Neuroinflammation: Outlook Beyond TSPO

Neil Vasdev's research focuses on the Tau protein - also implicated in Alzheimer's disease -, traumatic brain injury or inflammation of the brain in mental illness. The results of his research are applied worldwide and have contributed to the first neuroimaging studies in humans.
5:30 - 6:30 p.m
Agneta Nordberg

Q&A Session

Agneta Nordberg is an expert in the field of dementia research and recognized worldwide for her contribution to medical research and, in particular, to Alzheimer’s disease. She will lead the subsequent debate with the speakers and attendees and will contribute to add value to the discussed considerations.

Molecular Biomarkers of Neurodegeneration

4:30 p.m
Agustín Ruiz

Welcome

Agustín Ruiz, Research Director at Ace Alzheimer Center, has dedicated his career to human molecular genetics and is co-inventor of 6 genomics patents. His contribution to the knowledge of the genetic bases of human diseases is supported by more than 161 articles published in indexed international journals.
4:40 p.m
Henrik Zetterberg

Current status of CSF-based biomarkers for the diagnosis and prognosis of Alzheimer’s disease

With a background in molecular biology and medicine, Henrik Zetterberg has spent the last 10 years developing biomarkers for Alzheimer's disease and other brain disorders. He has developed new diagnostic tests for Alzheimer’s disease, as well as new preclinical models, and has shown that amyloid pathology precedes tau pathology by around five years during the Alzheimer’s disease process in humans, altered amyloid homeostasis in the brain is evident already in pre-symptomatic stages of the disease, and the diagnostic usefulness of Alzheimer’s biomarkers decreases with age due to increased prevalence of preclinical Alzheimer neuropathology.
5:05 p.m
Michelle M Mielke

Current status of blood-based biomarkers for the diagnosis and prognosis of Alzheimer’s disease

Dr. Mielke works as a translational epidemiologist to further understanding of the etiology and epidemiology of neurodegenerative diseases. One focus of her research is the identification of fluid biomarkers for the diagnosis, prediction, and progression of Alzheimer's disease and other neurodegenerative diseases. Another focus of Dr. Mielke’s research is on understanding sex and gender differences in the development and progression of Alzheimer’s disease and of other aging-related conditions.
5:30 - 6:30 p.m
Charlotte Teunissen

Q&A Session

Charlotte Teunissen’s mission is to improve care of patients with neurological diseases by developing body fluid biomarkers for diagnosis, stratification, prognosis and monitoring treatment responses. Studies of her research group cover the entire spectrum of biomarker development, starting with biomarker identification, followed by biomarker assay development and analytical validation, and extensive clinical validation to ultimately implement novel biomarkers in clinical practice.

Blood Circulating factors contributing to dementia pathophysiology

4:30 p.m
Mercè Boada

Welcome

Mercè Boada is founder and medical director of Ace Alzheimer Center. Her focus in research is on the treatment of Alzheimer's disease and related dementias, especially on the genotype and phenotype of common degenerative diseases and the design of new pharmacological and non-pharmacological treatments.
4:40 p.m
Tony Wyss-Coray

Blood factors as regulators of brain ageing and function

Tony Wyss-Coray is the D.H. Chen distinguished professor of neurology and neurological sciences at Stanford University. His lab studies brain aging and neurodegeneration with a focus on age-related cognitive decline and Alzheimer’s disease. His research team discovered that circulatory blood factors can modulate brain structure and function and that factors from young organisms can rejuvenate old brains. His current studies focus on the molecular basis of systemic communication with the brain by employing a combination of genetic, cell biology and -omics approaches in killifish, mice and humans and through the development of bio-orthogonal tools for the in vivo labelling of proteins.
5:05 p.m
Berislav Zlokovic

Blood-brain barrier link to neurodegeneration: implications for cognitive impairment and Alzheimer's disease

Berislav V. Zlokovic is the director of the Zilkha Neurogenetic Institute and Professor and Chair of the Department of Physiology & Neuroscience at the Keck School of Medicine of USC, and a Professor of Biological Sciences at the Dornsife College of Letters, Arts and Sciences. Zlokovic studies the role of brain microcirculation, particularly the blood-brain barrier (BBB) in health and disease in the adult brain and during brain aging. He made major contributions to our understanding of the role of BBB in the pathogenesis and treatment of Alzheimer’s disease (AD) and stroke.
5:30 - 6:30 p.m
Chris R Butler

Q&A Session

Chris Butler is the Clinical Senior Lecturer and Honorary Consultant Neurologist in the Department of Brain Sciences at Imperial College London. Dr. Butler research focusses on understanding the memory deficits experienced by patients with damage to the medial temporal lobes of the brain due to limbic encephalitis, epilepsy and Alzheimer's disease. He uses behavioural measures, brain imaging (MRI and MEG) and intracranial EEG recording to investigate memory and its impairment in neurological disease.
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